Ascorbate, a water-soluble vitamin, is suggested to play a role in modulating the synaptic effects of dopamine and glutamate. To investigate this issue, ascorbate release will be monitored with an electrochemically modified carbon-fiber electrode in the neostriatum and other forebrain regions in freely moving animals. Various manipulations, including lesions and intracerebral infusions, will assess the involvement of several extrastriatal systems in neostriatal ascorbate release. Functional interactions of ascorbate with dopamine and glutamate will be examined with single-unit recordings. Parallel studies will assess both dopaminergic and glutaminergic mechanisms underlying the behavioral supersensitivity to dopamine agonists, which has been shown to occur during withdrawal from long-term ascorbate treatment.

Agency
National Science Foundation (NSF)
Institute
Division of Integrative Organismal Systems (IOS)
Type
Standard Grant (Standard)
Application #
9112055
Program Officer
Stacy Springer
Project Start
Project End
Budget Start
1991-09-01
Budget End
1996-02-29
Support Year
Fiscal Year
1991
Total Cost
$220,986
Indirect Cost
Name
Indiana University
Department
Type
DUNS #
City
Bloomington
State
IN
Country
United States
Zip Code
47401