Abstract

32 chemicals (18 developmental toxicants, 7 neurotoxicants, 5 unknowns, and 3 negative controls) will be evaluated with a battery of assays in zebrafish embryos. The maximum tolerated concentration will be determined with 5 concentrations/compound (0.1-1000 ?M). Developmental toxicity, ototoxicity and compound bioavailability (internal concentration) will be evaluated following compound exposure for 96 hr (n=15).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource and Support Contracts (N02)
Project #
273201600003P-0-0-1
Application #
9367518
Study Section
Project Start
2015-10-16
Project End
2016-10-15
Budget Start
Budget End
Support Year
Fiscal Year
2016
Total Cost
Indirect Cost