The VCU proposes a renovation project that will transform 10,974 sq. ft. of outdated office and laboratory space, located on the second floor of Sanger Hall (a 40-year-old medical sciences building) into a Cellular and Molecular Signaling Facility for collaborative research and training. Specifically, the renovated space will house Principal Investigators (PIs) studying cellular signaling processes that contribute to: cancer, cardiovascular and nervous system dysfunction, diabetes, inflammatory diseases, and substance abuse. Thus, this facility will unite and centralize these researchers, and will serve as an environmental catalyst for new collaborations and research efforts. This in turn will lead to knowledge sharing and new funding initiatives, which will result in new advances and discoveries. The motivation for this application is two-fold: 1) the current laboratory facilities are outdated, confined, and inadequate for currently funded research; and 2) recruiting strong research-oriented faculty and graduate students is hindered by lack of adequate facilities. The newly designed laboratory space will offer: an open design to promote collaboration among co-workers, computer and desk space for PIs and graduate students, and specialized areas for equipment sharing and implementation of modern techniques. Once completed, the renovated space will not only enhance the ability of VCU researchers to conduct currently funded projects, but will also improve the likelihood of future funding. The long-term objective of this application is to provide new infrastructure that will stimulate the development of a nationally recognized center of expertise in the field of cellular and molecular signaling.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Facilities Construction Grant (C06)
Project #
1C06RR017393-01
Application #
6531477
Study Section
Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities (STRB)
Program Officer
Mccullough, Willie
Project Start
2002-06-01
Project End
2005-11-30
Budget Start
2002-06-01
Budget End
2005-11-30
Support Year
1
Fiscal Year
2002
Total Cost
$1,995,367
Indirect Cost
Name
Virginia Commonwealth University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Karandashova, Sophia; Kummarapurugu, Apparao B; Zheng, Shuo et al. (2018) Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase. Am J Physiol Lung Cell Mol Physiol 314:L206-L214
DeLigio, James T; Lin, Grace; Chalfant, Charles E et al. (2017) Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. J Biol Chem 292:17909-17918
Stephenson, Daniel J; Hoeferlin, L Alexis; Chalfant, Charles E (2017) Lipidomics in translational research and the clinical significance of lipid-based biomarkers. Transl Res 189:13-29
Shapiro, Brian A; Vu, Ngoc T; Shultz, Michael D et al. (2016) Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKC? Signaling Axis. J Biol Chem 291:21669-21681
Kolawole, Elizabeth Motunrayo; McLeod, Jamie Josephine Avila; Ndaw, Victor et al. (2016) Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. J Immunol 196:1461-70
Barbour, Suzanne E; Nguyen, Phuong T; Park, Margaret et al. (2015) Group VIA Phospholipase A2 (iPLA2?) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in ?-Cells. J Biol Chem 290:11021-31
Priyadarsini, Shrestha; Sarker-Nag, Akhee; Allegood, Jeremy et al. (2015) Description of the sphingolipid content and subspecies in the diabetic cornea. Curr Eye Res 40:1204-10
Dhall, Sandeep; Wijesinghe, Dayanjan Shanaka; Karim, Zubair A et al. (2015) Arachidonic acid-derived signaling lipids and functions in impaired healing. Wound Repair Regen 23:644-56
van den Elsen, Lieke W J; Spijkers, Léon J A; van den Akker, Rob F P et al. (2014) Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats. J Hypertens 32:1050-8; discussion 1058
Wijesinghe, Dayanjan S; Brentnall, Matthew; Mietla, Jennifer A et al. (2014) Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res 55:1298-309

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