State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishments, and the use of the first person. This description is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Major environmental health problems confront the ^developing world as it faces the problems associated with poverty, over-crowding, indoor and outdoor air pollution, and industrial development. Nowhere is this more apparent than in India. On top of these problems, West Bengal has been confronted with widespread contamination of drinking water with arsenic to an extent that, in conjunction with neighboring Bangladesh, is without parallel in world history. The proposed continuation of the Berkeley International Research and Training Program In Environmental and Occupational Health will focus on two areas: arsenic in drinking water in West Bengal, and indoor air pollution including its impact on tuberculosis throughout India. Collaborating Institutions include one in Calcutta, West Bengal, for arsenic research training, and three centers for air pollution research training in Lucknow, Chennai, and New Delhi. The major approach will involve selecting trainees who with undertake supervised activities in research and intervention in India with local faculty, along with-faculty from Berkeley who are conducting collaborative research investigations with local scientists. Funding for the actual research work will primarily come from existing or pending collaborative research grants. The in-country training will be supplemented by short-term training at the University of California, Berkeley, with selected faculty chosen based on trainee needs. Where applicable, degrees, such as PhD's would be awarded by in-county institutions. Some one week long in-country training courses will also be given, and a small number of trainees will be admitted for long-term training in Berkeley.. The overall goal of this program is to provide training and enhance research skills for local scientists to assess major environmental health problems in India, and to plan and evaluate appropriate prevention and intervention strategies. PERFORMANCE SITE(S) (organization, city, state) University of California, Berkeley, School of Public Health 140 Earl Warren Hall, Berkeley, CA 94720-7360 KEY PERSONNEL. See instructions on Page 11. Use continuation pages as neededto provide the required information in the format shown below. Name Allan H. Smith Kirk R. Smith Gladys Block John Balmes Brenda Eskenazi David A. Kalman Arthur Reingold Steve Selvin Martyn T. Smith Gayle Windham Organization Role on Project UC Berkeley, COEH Program Director,Mentor UC Berkeley, COEH Asst Director, Mentor UC Berkeley, Nutr Sci Mentor UC San Francisco, COEH Mentor UC Berkeley, COEH Mentor University of WA, EHS Mentor UC Berkeley, Epid Mentor UC Berkeley, Biostats Mentor UC Berkeley, COEH Mentor State of CA, Hlth Srvcs Mentor PHS 398 (Rev. 4/98) Page 2->- , f* BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a. 3b. NN ^ Program Director (las?, first, middle) Type the name of the program director at the top oWKh printed page and each continuation page. (Fortype ^Unifications, see instructions on page 6.) INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARD (Substitute Page)

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
3D43TW000815-10S1
Application #
7243978
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Schonwalder, Chris
Project Start
1996-09-30
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2007-04-30
Support Year
10
Fiscal Year
2006
Total Cost
$154,000
Indirect Cost
Name
University of California Berkeley
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Paul, Somnath; Das, Nandana; Bhattacharjee, Pritha et al. (2013) Arsenic-induced toxicity and carcinogenicity: a two-wave cross-sectional study in arsenicosis individuals in West Bengal, India. J Expo Sci Environ Epidemiol 23:156-62
Pokhrel, Amod K; Bates, Michael N; Shrestha, Sachet P et al. (2013) Biomass stoves and lens opacity and cataract in Nepalese women. Optom Vis Sci 90:257-68
Lakshmi, P V M; Virdi, Navkiran Kaur; Thakur, J S et al. (2012) Biomass fuel and risk of tuberculosis: a case-control study from Northern India. J Epidemiol Community Health 66:457-61
Das, Nandana; Paul, Somnath; Chatterjee, Debmita et al. (2012) Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India. BMC Public Health 12:639
Banerjee, Nilanjana; Nandy, Sujay; Kearns, James K et al. (2011) Polymorphisms in the TNF-? and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects. Toxicol Sci 121:132-9
Basu, Arin; Mitra, Soma; Chung, Joyce et al. (2011) Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India. Environ Health Perspect 119:1308-13
Johnson, Priscilla; Balakrishnan, Kalpana; Ramaswamy, Padmavathi et al. (2011) Prevalence of chronic obstructive pulmonary disease in rural women of Tamilnadu: implications for refining disease burden assessments attributable to household biomass combustion. Glob Health Action 4:7226
Pokhrel, Amod K; Bates, Michael N; Verma, Sharat C et al. (2010) Tuberculosis and indoor biomass and kerosene use in Nepal: a case-control study. Environ Health Perspect 118:558-64
Hira-Smith, Meera M; Yuan, Yan; Savarimuthu, Xavier et al. (2007) Arsenic concentrations and bacterial contamination in a pilot shallow dugwell program in West Bengal, India. J Environ Sci Health A Tox Hazard Subst Environ Eng 42:89-95
von Ehrenstein, Ondine S; Poddar, Shalini; Yuan, Yan et al. (2007) Children's intellectual function in relation to arsenic exposure. Epidemiology 18:44-51

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