The purpose of the proposed studies is to investigate the role of estrogen on mood and behavior in normal healthy menstruating women. One goal is to investigate the mood-altering and behavioral effects of varying concentrations of estrogen, first as a result of normal physiological fluctuations that occur naturally across the menstrual cycle, and second as a result of exogenous administration of single doses of transdermal estrogen. The second goal is to investigate interactions between estrogen and a stimulant drug, d- amphetamine. This combination will be studied both during the course of the normal cycle, and after exogenous administration of both estrogen and amphetamine. It is hypothesized that estrogen will produce mood-enhancing effects, and that the effects of d- amphetamine will be greater in the presence of higher levels of estrogen. These interactions are expected because both estrogen and d-amphetamine enhance activity of the dopaminergic system in the brain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH012243-02
Application #
6185158
Study Section
Treatment Assessment Review Committee (TA)
Program Officer
Altman, Fred
Project Start
2000-07-01
Project End
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
2
Fiscal Year
2000
Total Cost
$27,945
Indirect Cost
Name
University of Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637