Abstract

Schistosomiasis is a re-emerging disease as its incidence has increased in humans over the past decade. It currently afflicts some 200 million individuals in 76 countries of the world. Its main impact is to dehabilitate populations although 800,000 people succumb to the disease. This training grant will strengthen our current research program in Brazil and allow us to build sustainable research capacity at the Centro des Pesquisas Rene Rachou, FIOCRUZ by establishing research programs in genetic epidemiologic and geographic information systems to enhance ongoing immunological field research, strengthen existing programs in immunology, bioinformatics and interest established American scientists in emerging and reemerging diseases. We propose long-term training of 4 postdoctoral fellows, two years each, mid- and short-term training coupled with workshops to have an immediate impact on our research and to attract the interest of the Brazilian scientific community. This training grant is expected to strengthen the capacity of American and Brazilian scientists associated with the Centro des Pesquisas Rene Rachou and the International Center for Infectious Diseases Research Program through studies on schistosomiasis to understand and respond to a reemerging infectious disease and with further training to outbreaks of any infectious disease. ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006580-06
Application #
7217967
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (90))
Program Officer
Sina, Barbara J
Project Start
2003-09-01
Project End
2008-09-30
Budget Start
2007-04-01
Budget End
2008-09-30
Support Year
6
Fiscal Year
2007
Total Cost
$133,950
Indirect Cost

  Institution

Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Scholte, Ronaldo G C; Freitas, Corina C; Dutra, Luciano V et al. (2012) Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. Acta Trop 121:112-7
Simões, Mariana C; Lee, Jonathan; Djikeng, Appolinaire et al. (2011) Identification of Schistosoma mansoni microRNAs. BMC Genomics 12:47
Kloos, Helmut; Correa-Oliveira, Rodrigo; dos Reis, Dener Carlos et al. (2010) The role of population movement in the epidemiology and control of schistosomiasis in Brazil: a preliminary typology of population movement. Mem Inst Oswaldo Cruz 105:578-86
Carvalho, Omar S; Scholte, Ronaldo G C; Guimaraes, Ricardo J P S et al. (2010) The Estrada Real project and endemic diseases: the case of schistosomiasis, geoprocessing and tourism. Mem Inst Oswaldo Cruz 105:532-6
Reis, Dener Carlos dos; Kloos, Helmut; King, Charles et al. (2010) Accessibility to and utilisation of schistosomiasis-related health services in a rural area of state of Minas Gerais, Brazil. Mem Inst Oswaldo Cruz 105:587-97
Pereira, Wesley Rodrigues; Kloos, Helmut; Crawford, Sara B et al. (2010) Schistosoma mansoni infection in a rural area of the Jequitinhonha Valley, Minas Gerais, Brazil: analysis of exposure risk. Acta Trop 113:34-41
Berriman, Matthew; Haas, Brian J; LoVerde, Philip T et al. (2009) The genome of the blood fluke Schistosoma mansoni. Nature 460:352-8
Valentim, Claudia L L; LoVerde, Philip T; Anderson, Timothy J C et al. (2009) Efficient genotyping of Schistosoma mansoni miracidia following whole genome amplification. Mol Biochem Parasitol 166:81-4
Criscione, Charles D; Valentim, Claudia L L; Hirai, Hirohisa et al. (2009) Genomic linkage map of the human blood fluke Schistosoma mansoni. Genome Biol 10:R71
Fantappie, Marcelo Rosado; Bastos de Oliveira, Francisco Meirelles; de Moraes Maciel, Renata et al. (2008) Cloning of SmNCoA-62, a novel nuclear receptor co-activator from Schistosoma mansoni: assembly of a complex with a SmRXR1/SmNR1 heterodimer, SmGCN5 and SmCBP1. Int J Parasitol 38:1133-47

Showing the most recent 10 out of 23 publications