We propose to establish the University of Pittsburgh (Pitt) HIV Research Training Program in Mozambique (Pitt HRTP). The purpose of the program is to build research capacity at the Catholic University of Mozambique, located in the port city of Beira, for the conduct of HIV clinical trials. This program is an extension of the Pitt AIDS International Training and Research Program (AITRP), which was established in 1998 and has been building research capacity at UCM since 2009. Previously, the Pitt AITRP contributed substantially to building research capacity in Brazil for the development of HIV Vaccine Trials Network (HVTN) sites in Rio de Janeiro and Sjo Paulo. The Pitt HRTP will be directed by Dr. Lee Harrison, Professor of Epidemiology and Medicine, who was also the Director of the Pitt AITRP. A broad array of non- degree and degree training opportunities will be available in epidemiology and biostatistics, laboratory sciences, behavioral sciences, and other fields relevant to clinical trials. Participating training sites are Pitt;the Federal University of Rio d Janeiro (UFRJ), Brazil;the University of Stellenbosch (SU), Cape Town, South Africa;and the Manhija Health Research Center (CISM), Manhija, Mozambique. The program includes a multidisciplinary group of experienced mentors and excellent training opportunities at each site. The inclusion of UFRJ, SU, and CISM provides substantial opportunities for """"""""south-to-south"""""""" training. Trainees will have access to all of the relevant resources of the participating institutions. A key measure of program success will be the participation of UCM in HIV clinical trials by the end of the five-year funding period.

Public Health Relevance

We propose a research training program at the Catholic University of Mozambique which has as its primary goal the enhancement of research capacity for the conduct of HIV clinical trials. This will be accomplished by an expert; multidisciplinary team of research mentors and excellent training opportunities at the University of Pittsburgh; Pittsburgh; USA; the Federal University of Rio de Janeiro (UFRJ); Rio de Janeiro; Brazil; the University of Stellenbosch (SU); Cape Town; South Africa; and the Manhi a Health Research Center (CISM); Manhi a; Mozambique. By the end of the five-year funding period; we anticipate that UCM will be participating in HIV clinical trials.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
1D43TW009753-01
Application #
8707111
Study Section
Special Emphasis Panel (ZRG1-AARR-H (57))
Program Officer
Mcdermott, Jeanne
Project Start
2014-05-09
Project End
2019-03-31
Budget Start
2014-05-09
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$291,065
Indirect Cost
$19,657
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Other Domestic Higher Education
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Feliciano, Cinara Silva; Namburete, Evangelina Inacio; Rodrigues Plaça, Jéssica et al. (2018) Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique. Tuberculosis (Edinb) 110:59-67
Bollela, V R; Namburete, E I; Feliciano, C S et al. (2016) Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis. Int J Tuberc Lung Dis 20:1099-104
Namburete, Evangelina Inácio; Tivane, Inês; Lisboa, Miguelhete et al. (2016) Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing. BMC Infect Dis 16:423
Dubé, Karine; Zango, Arlinda; van de Wijgert, Janneke et al. (2014) HIV incidence in a cohort of women at higher risk in Beira, Mozambique: prospective study 2009-2012. PLoS One 9:e84979
Meque, Ivete; Dubé, Karine; Feldblum, Paul J et al. (2014) Prevalence, incidence and determinants of herpes simplex virus type 2 infection among HIV-seronegative women at high-risk of HIV infection: a prospective study in Beira, Mozambique. PLoS One 9:e89705