Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
5DP1OD000379-02
Application #
7128511
Study Section
Special Emphasis Panel (ZGM1-NDPA-G (P3))
Program Officer
Jones, Warren
Project Start
2005-09-30
Project End
2010-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
2
Fiscal Year
2006
Total Cost
$825,142
Indirect Cost

  Institution

Name
Rockefeller University
Department
Anatomy/Cell Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Davoli, Teresa; de Lange, Titia (2011) The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol 27:585-610
de Lange, T (2010) How shelterin solves the telomere end-protection problem. Cold Spring Harb Symp Quant Biol 75:167-77
Gong, Yi; de Lange, Titia (2010) A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Mol Cell 40:377-87
Davoli, Teresa; Denchi, Eros Lazzerini; de Lange, Titia (2010) Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141:81-93
de Lange, Titia (2009) How telomeres solve the end-protection problem. Science 326:948-52
Dimitrova, Nadya; Chen, Yi-Chun M; Spector, David L et al. (2008) 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456:524-8
Konishi, Akimitsu; de Lange, Titia (2008) Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev 22:1221-30