We propose to integrate modern bioengineering techniques with psychiatry. We will launch a large-scalesystematic operation, driven by modern bioengineering tools and principles, to map key neural circuitdynamics with millisecond temporal resolution. Outcomes of this work will include fundamental newconceptualizations of neuropsychiatric disease, a wealth of basic neuroscience and bioengineeringinsights, and potent, specific circuit-modulation interventions for treatment of neuropsychiatric disease.
Kumar, C Ranjith; Suguna, S (2016) Visual Semantic Based 3D Video Retrieval System Using HDFS. Data Min Knowl Discov 10:3806-3825 |
Chung, Kwanghun; Wallace, Jenelle; Kim, Sung-Yon et al. (2013) Structural and molecular interrogation of intact biological systems. Nature 497:332-7 |
Mei, Yuan; Zhang, Feng (2012) Molecular tools and approaches for optogenetics. Biol Psychiatry 71:1033-8 |
Stroh, Albrecht; Tsai, Hsing-Chen; Wang, Li-Ping et al. (2011) Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells 29:78-88 |
Tye, Kay M; Prakash, Rohit; Kim, Sung-Yon et al. (2011) Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471:358-62 |
Yizhar, Ofer; Fenno, Lief E; Prigge, Matthias et al. (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477:171-8 |
Witten, Ilana B; Steinberg, Elizabeth E; Lee, Soo Yeun et al. (2011) Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron 72:721-33 |
Fenno, Lief; Yizhar, Ofer; Deisseroth, Karl (2011) The development and application of optogenetics. Annu Rev Neurosci 34:389-412 |
Yizhar, Ofer; Fenno, Lief E; Davidson, Thomas J et al. (2011) Optogenetics in neural systems. Neuron 71:9-34 |
Witten, Ilana B; Lin, Shih-Chun; Brodsky, Matthew et al. (2010) Cholinergic interneurons control local circuit activity and cocaine conditioning. Science 330:1677-81 |
Showing the most recent 10 out of 11 publications