Abstract

A mathematical method to analyze a model of common disease inheritance using marker genes wilt be work out. It consists in forming (1) a set of hypotheses about the mode of inheritance of a human trait (disease predisposition) and its connection with marker loci, and (2) a set of statistics or non-statistical characteristics to reveal any deficiency of a hypothesis. If a hypothesis is """"""""compromised"""""""", it is to be rejected, reducing a set of rival hypotheses and of inheritance mechanisms. Recurrence risks will be calculated based on parameters estimated. Pedigrees will be used as data to estimate model parameters by the method of maximum likelihood.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Fellowships (FIC) (F05)
Project #
5F05TW005285-02
Application #
2546737
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Program Officer
Mandes, Silvia
Project Start
1997-09-30
Project End
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Drigalenko, E (1999) Matrix representation of the Haseman-Elston method. Theor Popul Biol 55:157-65
Drigalenko, E; Poduslo, S; Elston, R (1998) Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer's disease. Neurology 51:131-5
Drigalenko, E (1998) How sib pairs reveal linkage. Am J Hum Genet 63:1242-5
Drigalenko, E (1998) Allele identical by descent sharing at any point of a chromosome of a sib pair. Am J Hum Genet 63:1245-7
Drigalenko, E I; Elston, R C (1997) False discoveries in genome scanning. Genet Epidemiol 14:779-84