Abstract

MR-guidedin-gantryprostatebiopsyisastate-of-the-arttechniquethathasconsiderableadvantagesover otherprostatebiopsymethods,includingincreasedlesiontargetingaccuracyandfewersideeffectswith shorterrecoverytimes.However,performingtheprocedureisdifficultandtime-consumingduetoavarietyof factors.High-resolutionT2-weightedimagesusedtoguidetheneedlehavelongacquisitiontimesresultingin slowneedleadjustments.Furthermore,guidanceinMR-guidedbiopsyreliesonsupportsoftwarethatisprone toerrorduetodifferentgeometrybetweenbiopsyplanningandguidanceimages.Manualvisualguidance, oftendonetocompensateforerrorswithsupportsoftware,canbeinaccurateduetoslowpaceofvisual feedback,leadingtorepeatguidanceimagescansandthuslongerproceduretimes.Hence,anewwayto approachimagingandvisualizationofdatainMR-guidedprostatebiopsyisanecessarysteptoreduce procedurecomplexityanddurationandimprovepatientaccessibilitytothisdiagnostictechnique. AguidanceimageinMR-guidedbiopsyrequires40-60secondstoacquire.ProgressmadeinCase WesternReserveUniversity(CWRU)MRIresearchgrouphasenabledfastimagingthatcanaccelerateimage collectionbymorethanahundred-fold.FastMRmethoddevelopmentwillbuilduponcurrentlyutilizedfastspin echoimagingmethodologyandintegrateadvancementsinnon-traditionaldatasamplingtechniquesand parallelimagingtoenablecollectionofguidanceimagesinafewseconds.Rapidlyacquiredguidanceimages willprovidesuperiortemporalresolutiontocurrenttechniquewithsufficientimagequalitytoenableaccurate targetingoflesionsinMR-guidedprostatebiopsy. WhilefastimageacquisitionimprovesthetemporalresolutionofvisualfeedbackinMR-guidedprostate biopsy,procedurecomplexityarisesfromimagingindifferentimagingplanesbetweenplanningandguidance imagesandtargetinglesionsthathaveinsufficientcontrastintheseimages.Non-rigidimageregistrationwill enablevisualfusionbetweennotonlyplanningandguidanceimages,butalsohigherqualitypre-biopsy diagnosticimageswhichprovidebettertissuecontrastforlesiontargeting.Augmentedrealityholographic renderingwillbeimplementedinconjunctionwithimageregistrationtovisualizethecomplex3Dspatial relationshipsbetweenthedifferentimagedatasets.Thecombinationofimageregistrationandholographic visualizationwillprovidemoreinformativespatialinformationduringMR-guidedprostatebiopsy,allowing radiologiststobetterutilizetheirtrainedintuitionandthusreducingprocedurecomplexityandrelianceon supportsoftwareforlesiontargeting. Together,fastMRimagingandaugmentedrealityvisualizationtechniquesproposedhereinwillreduce proceduretimeanddifficulty,therebyhelpingincreaseadoptionandpatientaccessibilitytoMR-guidedprostate biopsy.

Public Health Relevance

Currenttransrectalultrasoundguidedprostatebiopsyrequiressystematicsamplingoftheprostatedueto inabilitytoaccuratelyidentifyfociofdisease,resultinginfalsenegativesandrepeatbiopsiesthatincrease patientanxietyandriskofpost-procedurecomplications.In-gantrymagneticresonanceguidedprostatebiopsy hasdemonstratedgreatervaluetoprostatecancerdiagnosisbyincreasingbiopsyaccuracy,andthusreducing theneedforrepeatbiopsies;?however,thetechniqueistime-consumingaswellasdifficulttoteachand performwhichhaspreventedwidespreadadoption.WeproposenovelfastMRimagingandaugmentedreality visualizationtechniquesthatwillmakeMR-guidedbiopsyfasterandmoreintuitivetoperform.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
1F30CA239355-01A1
Application #
9911196
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Damico, Mark W
Project Start
2020-01-01
Project End
2022-12-31
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106