A novel receptor for platelet-activating factor (PAF) has been identified and shown to be highly enriched in the cerebral cortex. PAF is known to play a role in neuronal development, long-term potentiation, and brain injury, in addition to its role as a potent mediator of inflammation in the periphery. Characterization and molecular cloning of the cytosolic receptor will shed insight on how the many effects of PAF are mediated. In this proposal we describe experiments directed towards characterization and purification of this protein which will enable us to molecularly clone the gene for this novel receptor.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
5F30DA005900-06
Application #
6649283
Study Section
Special Emphasis Panel (ZDA1-MXS-M (01))
Program Officer
Babecki, Beth
Project Start
2002-09-01
Project End
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
6
Fiscal Year
2003
Total Cost
$47,184
Indirect Cost
Name
Johns Hopkins University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218