The long-term objective of the proposed research is to understand development of the mushroom bodies, structures important for learning and memory in Drosophila melanogaster. Toward this goal, I am studying the function of the novel protein DACHSHUND. Our interest in the dachshund phenotype stems from its abnormal mushroom body structure, although mutant flies also have reduced, roughened eyes and short legs and die shortly after eclosion. Dachshund is the first cloned gene to be associated with mushroom body structural defects. To dissect dachshund's role in mushroom body development, I am proposing three specific aims: (1) Determine if the mushroom body structural defect in dac mutants is cell autonomous. (2) Ascertain when DACHSHUND is required for proper mushroom body formation. (3) Assess dachshund's role in mushroom body fate determination. Dachshund has previously been shown to direct eye formation when ectopically expressed in imaginal discs. The presence of dachshund vertebrate homologs suggests conservation of a molecular and developmental pathway through evolution. If this is indeed the case, studying dachshund's role in mushroom body development could elucidate developmental principles at work in the mammalian brain. Such conservation would not be surprising, since the biochemical pathways involved in learning have been conserved from Aplysia to Drosophila to mammals. If a developmental pathway for structures involved in learning has also been conserved, studying dachshund may help us understand cognitive deficits in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
5F30MH011912-03
Application #
6185097
Study Section
Molecular, Cellular, and Developmental Neurobiology Review Committee (MCDN)
Program Officer
Wynne, Debra K
Project Start
2000-07-01
Project End
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
3
Fiscal Year
2000
Total Cost
$23,752
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030