B-cell development and receptor editing and the role in disease. My first year I will be involved in three rotations in different fields of Immunology. I am very interested in understanding B-cell development and disease states. With a better understanding of B cell development, it may be possible to apply knowledge to remedy or cure aberrant states such as Autoimmunity. From prior participation in research I have identified an area of great interest. I participated in a project on the Immune dysregulation that leads to (IBD) inflammatory bowel disease. The focus of the present lab is different from my previous laboratory experience, however, I have already tried and tested some of my interests. Although my interests are broad I have developed a strong interest in the field of immunology.
| Vela, Jose Luis; Ait-Azzouzene, Djemel; Duong, Bao Hoa et al. (2008) Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity 28:161-70 |
| Verkoczy, Laurent; Duong, Bao; Skog, Patrick et al. (2007) Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol 178:6332-41 |
| Ait-Azzouzene, Djemel; Verkoczy, Laurent; Peters, Jorieke et al. (2005) An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J Exp Med 201:817-28 |
