18. GOALS FOR FELLOWSHIP TRAINING AND CAREER My goal is to complete both MD and PhD degrees in 7-8 years at Harvard Medical School. I hope to strengthen my grounding in the fundamentals of both clinical practice and basic research, in the process forge the two disciplines in my desired career. In research, I am primarily interested in topics in immunology. I am particularly interested in the creation of vaccines for sexually transmitted diseases. I would also like to continue to study the interactions of oral vaccines with the flora already present in the intestines, i.e. mechanisms of tolerance and immunity at mucosal surfaces. Through past research experiences at the NIH, Massachusetts General Hospital, and Merck, I realize that I can participate in basic research with significant clinical relevance. The pursuit of both medical and graduate education would give me the satisfaction of connecting so many of my interests, from biochemistry to community outreach, from sexual politics to STD prevention and care. 19. NAME AND DEGREE(S) Nancy 20. POSITION/RANK Associate 21. RESEARCH INTERESTS/AREAS Mouse models of human 22. DESCRIPTION (Do not exceed space No Thesis Selected. Co Andrews, M D., Ph.D. Professor,Pediatrics, Howard Hughes Assoc._ Director, MD-PhD Program, Harvard Medical School disease, hematopoiesis, iron transport il_1=1'i.i,_1i' '.:J[,]_,_-'_-'_ provided) My primary areas of research interest are encompassed by the field of immunology. I am interested in research in drug design and vaccine development. I am particularly interested in the creation of vaccines for sexually transmitted diseases. I would also like to continue to study the interactions of oral vaccines with the flora already present in the intestines and the mechanisms of tolerance and immunity at mucosal surfaces. PHS 416-1 (Rev. 12/98) Form Page 2 BB cc NAME (Last, first, middle initial) Individual NRSA Application Table of Contents ========================================Section End===========================================
| Iweala, Onyinye I; Smith, Donald W; Matharu, Kabir S et al. (2009) Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice. J Immunol 183:2252-60 |
| Matharu, Kabir S; Mizoguchi, Emiko; Cotoner, Carmen Alonso et al. (2009) Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology 137:1380-90.e1-3 |
| Iweala, Onyinye I; Nagler, Cathryn R (2006) Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal flora. Immunol Rev 213:82-100 |
