Abstract

During the fellowship award period, work will be centered on the development and formation of a three-dimensional matrix suitable for growth of osteoblast and osteoblast precursor cells. This novel approach will be taken to develop a system applicable to areas where bone regeneration is needed. Some examples are in the areas of fracture fixation, segmental bone defects and healing of cranial-facial bone injuries. If successful our research will allow us to optimize a three-dimensional matrix that is bioerodible, able to promote cell growth and possess mechanical properties similar to bone.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31AR008562-04
Application #
6626447
Study Section
Special Emphasis Panel (ZRG1-ALTX-4 (02))
Program Officer
Panagis, James S
Project Start
2002-01-01
Project End
2003-05-16
Budget Start
2003-01-01
Budget End
2003-05-16
Support Year
4
Fiscal Year
2003
Total Cost
$19,620
Indirect Cost

  Institution

Name
Drexel University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Friedman, Michael S; Long, Michael W; Hankenson, Kurt D (2006) Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem 98:538-54
Nishiwaki, Toru; Yamaguchi, Toru; Zhao, Chen et al. (2006) Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. J Bone Miner Res 21:596-604
Alford, Andrea I; Hankenson, Kurt D (2006) Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration. Bone 38:749-57
Hankenson, Kurt D; Ausk, Brandon J; Bain, Steven D et al. (2006) Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading. Bone 38:310-6
Hankenson, Kurt D; Hormuzdi, Sheriar G; Meganck, Jeffrey A et al. (2005) Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol 25:5599-606
El-Amin, Saadiq F; Kofron, Michelle D; Attawia, Mohamed A et al. (2004) Molecular regulation of osteoblasts for tissue engineered bone repair. Clin Orthop Relat Res :220-5
El-Amin, Saadiq F; Attawia, Mohamed; Lu, Helen H et al. (2002) Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone. J Orthop Res 20:20-8