The use of hallucinogens in our society, particularly adolescents and young adults, continues to be widespread and is thus a major interest of the National Institute on Drug Abuse.
The aim of the proposed project is to elucidate the modulatory role of serotonergic receptors of the 5-HTIA subtype in the actions of hallucinogens. This will be accomplished using behavioral and biochemical techniques to determine [a] the modulatory effects of 5-HT1A receptor agonists on stimulus control by DOM, a phenethylamine hallucinogen, [b] the specific role of 5-HT1A receptors of the dorsal and medial raphe nuclei in DOM induced stimulus control, [c] the role of G protein activation in the interactions of 5-HTIA agonists with DOM, and [d] possible serotonergic/glutamatergic interactions as they relate to 5-HT1A ligands. The behavioral variable in these studies will be DOM-induced stimulus control. Glutamate levels will be determined by in vivo microdialysis and HPLC. [35S] GTPgammaS binding will be used to identify molecular mechanisms involved in 5-HT1A receptor stimulation.
| Fantegrossi, William E; Reissig, Chad J; Katz, Elyse B et al. (2008) Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav 88:358-65 |
| Reissig, Chad J; Rabin, Richard A; Winter, Jerrold C et al. (2008) d-LSD-induced c-Fos expression occurs in a population of oligodendrocytes in rat prefrontal cortex. Eur J Pharmacol 583:40-7 |
| Winter, J C; Kieres, A K; Zimmerman, M D et al. (2005) The stimulus properties of LSD in C57BL/6 mice. Pharmacol Biochem Behav 81:830-7 |
| Reissig, C J; Eckler, J R; Rabin, R A et al. (2005) The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology (Berl) 182:197-204 |
| Eckler, J R; Reissig, C J; Rabin, R A et al. (2004) A 5-HT(2C) receptor-mediated interaction between 2,5-dimethoxy-4-methylamphetamine and citalopram in the rat. Pharmacol Biochem Behav 79:25-30 |
