Numerous investigations have implicated the nucleus accumbens (Acb) as a critical neural substrate that mediates the reinforcing effects of drugs of abuse such as cocaine. Previous studies in our laboratory have characterized cellular mechanisms underlying this process via electrophysiological recordings in behaving animals. These studies revealed that a subset of Acb neurons exhibit changes (increases or decreases) in firing rate synchronized to the self-administration of cocaine and are markedly influenced by drug-associated cues. Although we have shown that Acb cells are sensitive to interruption of the response-reinforcer contingency for cocaine and water reinforcement during an extinction paradigm, little is known about the effects of abstinence on Acb cell firing during cocaine self-administration. This is a critical issue since cocaine addiction in humans is typically characterized by cycles of abstinence from drug-taking and subsequent relapse. Thus, Exp. I will determine the firing properties of Acb neurons in rats well-trained to self-administer cocaine following various periods of cocaine abstinence (0, 4 and 8 weeks). Exp. II will examine the effects of cocaine abstinence on the activation of Acb neurons by cocaine-associated stimuli previously documented in our laboratory (Carelli 2000). Given that drug-associated cues are strong elicitors of 'craving' and relapse in humans, Exp. II will be directly relevant to understanding the biological basis of stimulus control in cocaine addiction. Collectively, these studies will provide important insight into the psychobiological consequences of interrupted drug access (abstinence), an important factor underlying relapse in human cocaine addicts.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA016989-02
Application #
6804050
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lawrence, Diane M
Project Start
2003-09-30
Project End
2006-09-29
Budget Start
2004-09-30
Budget End
2005-09-29
Support Year
2
Fiscal Year
2004
Total Cost
$27,408
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599