Abstract

The scientific goal of this project is to use magnetoencephalography (MEG) to gain a better understanding of the cortical networks involved in phonetic processing. Cortical sources involved in phonetic processing using whole-head MEG shall be investigated using novel tools to reconstruct their locations and time courses. Key technical developments to facilitate this work include methods to co-register and normalize MEG, ECoG, and structural MRI data. Cortical network connectivity during phonetic processing will also be examined using neural source reconstructions. To the extent possible, all analyses will be cross-validated with ECoG recordings in brain tumor patients. This project provides an interdisciplinary approach to studying important issues of neuronal activation and connectivity, using a multitude of techniques such as MEG, ECoG, and MRI. It also supports translational research with the potential to improve preoperative clinical language mapping procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DC006762-03
Application #
7036561
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2004-03-19
Project End
2007-03-18
Budget Start
2006-03-19
Budget End
2007-03-18
Support Year
3
Fiscal Year
2006
Total Cost
$28,975
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Guggisberg, Adrian G; Dalal, Sarang S; Schnider, Armin et al. (2011) The neural basis of event-time introspection. Conscious Cogn 20:1899-915
Mennella, Julie A; Beauchamp, Gary K (2008) Optimizing oral medications for children. Clin Ther 30:2120-32
Dalal, Sarang S; Guggisberg, Adrian G; Edwards, Erik et al. (2008) Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. Neuroimage 40:1686-700
Dalal, Sarang S; Guggisberg, Adrian G; Edwards, Erik et al. (2007) Spatial localization of cortical time-frequency dynamics. Conf Proc IEEE Eng Med Biol Soc 2007:4941-4
Dalal, Sarang S; Sekihara, Kensuke; Nagarajan, Srikantan S (2006) Modified beamformers for coherent source region suppression. IEEE Trans Biomed Eng 53:1357-63
Canolty, R T; Edwards, E; Dalal, S S et al. (2006) High gamma power is phase-locked to theta oscillations in human neocortex. Science 313:1626-8
Dalal, S S; Zumer, J M; Agrawal, V et al. (2004) NUTMEG: a neuromagnetic source reconstruction toolbox. Neurol Clin Neurophysiol 2004:52