This research is focused on assessing the inferior colliculus central nucleus (ICC) to primary auditory cortex (A1) neural projection using electrical stimulation (ES) of the ICC in a guinea pig model, in light of the development of a midbrain auditory prosthesis (MAP). Due to limitations of current auditory prostheses and the potential for improvements in frequency and level discrimination by ES of the ICC, experiments to determine the feasibility for a MAP are of interest. Therefore, it is important to study how the central auditory system organizes and processes sound information to assess how we might implement a MAP to achieve intelligible speech perception. A point-to-point tonotopic projection from the ICC to A1 has been shown. Thus, multi-channel electrodes will be used to electrically stimulate different ICC regions and simultaneously record neural activity across A1 to determine: (1) if segregated, parallel pathways from the ICC to A1 exist along the isofrequency dimension; and (2) if the temporal activation pattern along an isofrequency contour of A1 changes in response to ES of different regions within an isofrequency lamina of the ICC. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DC007009-02
Application #
6937680
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2004-08-01
Project End
2005-12-31
Budget Start
2005-08-01
Budget End
2005-12-31
Support Year
2
Fiscal Year
2005
Total Cost
$17,046
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lim, Hubert H; Lenarz, Minoo; Lenarz, Thomas (2009) Auditory midbrain implant: a review. Trends Amplif 13:149-80
Lim, Hubert H; Lenarz, Thomas; Anderson, David J et al. (2008) The auditory midbrain implant: effects of electrode location. Hear Res 242:74-85
Lim, Hubert H; Anderson, David J (2007) Antidromic activation reveals tonotopically organized projections from primary auditory cortex to the central nucleus of the inferior colliculus in guinea pig. J Neurophysiol 97:1413-27
Lim, Hubert H; Anderson, David J (2007) Spatially distinct functional output regions within the central nucleus of the inferior colliculus: implications for an auditory midbrain implant. J Neurosci 27:8733-43
Lim, Hubert H; Anderson, David J (2006) Auditory cortical responses to electrical stimulation of the inferior colliculus: implications for an auditory midbrain implant. J Neurophysiol 96:975-88
Lenarz, Minoo; Lim, Hubert H; Patrick, James F et al. (2006) Electrophysiological validation of a human prototype auditory midbrain implant in a guinea pig model. J Assoc Res Otolaryngol 7:383-98