Chemosensory signals activate brain regions along the vomeronasal and main olfactory pathways. In male hamsters, socially relevant chemosignals.from the same species of animal (conspecific) activate the anterior medal amygdala (MeA) and the posterior medialamygdala (MeP) and do not activate theGABATergic intercalated nucleus (ICN). Socially non-relevant chemosignals from other species activate MeA and ICN, but fail to activate MeP. Oxytocin knockout mice (OTKO) fail to recognize a conspecific that they have encountered previously. The cFos patterns in the medial amygdala suggest a heterospecific-like response to the stimulus animal. Therefore it is possible that oxytocin (OT) mediates the signal from the vomeronasal system in the medial amygdala allowing for """"""""downstream"""""""" continuation of the signal. These and other data suggest that oxytocin (OT) may affect medial amygdala responses to socially-relevant and socially non- relevant stimuli differently. This proposal will investigate OT effects in medial amygdala in response to conspecific and heterospecific chemosensory stimulation.
| Samuelsen, C L; Meredith, M (2011) Oxytocin antagonist disrupts male mouse medial amygdala response to chemical-communication signals. Neuroscience 180:96-104 |
| Samuelsen, Chad L; Meredith, Michael (2009) Categorization of biologically relevant chemical signals in the medial amygdala. Brain Res 1263:33-42 |
| Samuelsen, C L; Meredith, M (2009) The vomeronasal organ is required for the male mouse medial amygdala response to chemical-communication signals, as assessed by immediate early gene expression. Neuroscience 164:1468-76 |
