The objective of this research involves the synthesis of polycyclic heterocyclic systems, specifically, which will be used for the synthesis of natural products. The project involves novel methods towards the synthesis of 2-amido furans from pyrrolidinone intermediates. Cyclic amides are widely regarded as useful precursors for N-acyliminium ions. Cyclic carbinol amides were treated with triflic anhydride so as to prepare various alpha-triftuoromethylsulfonamido furans. The research will investigate whether the products can be used in subsequent cycloaddition chemistry for alkaloid synthesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31GM068992-01
Application #
6685554
Study Section
Special Emphasis Panel (ZRG1-F05 (29))
Program Officer
Gaillard, Shawn R
Project Start
2003-09-01
Project End
2007-03-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$40,934
Indirect Cost
Name
Emory University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322