Gonadotropin-releasing hormone (GnRH) neurons, a population of neuroendocrine cells located in the brain, produce and secrete GnRH, a neurohormone essential for vertebrate reproduction. Unlike most neurons in the brain, GnRH neurons are born outside the central nervous system in the embryonic nose. From the nose, GnRH neurons migrate into the brain and target their axons to the median eminence of the hypothalamus for GnRH release. GnRH neuron development expemplifies key processes of neuronal development, namely differentiation, cell migration and axon targeting. Currently, developmental regulation of these key events in GnRH neurons is not well understood. In this proposal, I hypothesize that the fibroblast growth factor (FGF) signaling contributes to the formation of a functional GnRH neurosecretory system. I propose FGFs directly regulate the differentiation of GnRH neurons during discrete stages of GnRH neuronal development. In developing GnRH neurons, the role of FGF signaling and contributing receptors (FGFRs) will be identified. Critical stages of GnRH neuron development will be evaluated in mice to discern the functional contribution of FGF signaling in this important neuroendocrine system. ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31HD047991-01
Application #
6829791
Study Section
Special Emphasis Panel (ZRG1-CDF-1 (29))
Program Officer
Henken, Deborah B
Project Start
2004-08-03
Project End
2006-03-31
Budget Start
2004-08-03
Budget End
2005-08-02
Support Year
1
Fiscal Year
2004
Total Cost
$26,882
Indirect Cost
Name
University of Colorado at Boulder
Department
Physiology
Type
Schools of Arts and Sciences
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309