Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31HG000144-04
Application #
2546127
Study Section
Special Emphasis Panel (SRC)
Project Start
1997-10-01
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Niles, Jacquin C; Wishnok, John S; Tannenbaum, Steven R (2006) Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide 14:109-21
Lee, Joseph M; Niles, Jacquin C; Wishnok, John S et al. (2002) Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines. Chem Res Toxicol 15:7-14
Niles, J C; Wishnok, J S; Tannenbaum, S R (2001) A novel nitroimidazole compound formed during the reaction of peroxynitrite with 2',3',5'-tri-O-acetyl-guanosine. J Am Chem Soc 123:12147-51
Niles, J C; Wishnok, J S; Tannenbaum, S R (2001) Spiroiminodihydantoin is the major product of the 8-oxo-7,8-dihydroguanosine reaction with peroxynitrite in the presence of thiols and guanosine photooxidation by methylene blue. Org Lett 3:963-6
Niles, J C; Wishnok, J S; Tannenbaum, S R (2000) A novel nitration product formed during the reaction of peroxynitrite with 2',3',5'-tri-O-acetyl-7,8-dihydro-8-oxoguanosine: N-nitro-N'-[1-(2,3,5-tri-O-acetyl-beta-D-erythro-pentofuranosyl)- 2, 4-dioxoimidazolidin-5-ylidene]guanidine. Chem Res Toxicol 13:390-6
Tretyakova, N Y; Niles, J C; Burney, S et al. (1999) Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine. Chem Res Toxicol 12:459-66
Burney, S; Caulfield, J L; Niles, J C et al. (1999) The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat Res 424:37-49
Burney, S; Niles, J C; Dedon, P C et al. (1999) DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite. Chem Res Toxicol 12:513-20