The proposed research will compare profiles of performance on executive function tasks in individuals with high-functioning autism (HFA), attention-deficit/hyperactivity disorder (ADHD), and schizophrenia, in order to help clarify the underlying cognitive deficit in each. In particular, two key dimensions of executive functions will be studies: working memory and inhibition. This study will directly compare profiles of executive function across these three populations at comparable ages and developmental levels. In addition, verbal working memory, nonverbal working memory, and inhibition will be examined within a single clinical sample, to directly compare different components of executive functions. It is predicted that, compared to matched controls without disabilities (n=20), adults with HFA (n=20) will have working memory impairments, wit verbal working memory showing greater impairments than nonverbal working memory, but inhibition will be intact. Adults with ADHD (n=20) will have intact working memory, but inhibition will be impaired, while adults with schizophrenia will show impairment in both working memory and inhibition. If profile differences are found, the result will provide further evidence that some aspects of executive function are specific to certain disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH011749-01A1
Application #
2516600
Study Section
Clinical Psychopathology Review Committee (CPP)
Project Start
1998-03-29
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Denver
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80208