Abstract

The proposed research is designed to elucidate the functional nature of the cholinergic system in a transgenic mouse model of Alzheimer's disease. The results of the proposed research will lead to crucial insights into the mechanisms which may underlie AD pathology, as well as paving the way for a possible treatment for this neurodegenerative disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH011834-02
Application #
6185757
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (02))
Program Officer
Wynne, Debra K
Project Start
2000-09-22
Project End
2001-08-27
Budget Start
2000-09-22
Budget End
2001-08-27
Support Year
2
Fiscal Year
2000
Total Cost
$21,009
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Neurology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Westerman, Marcus A; Cooper-Blacketer, Deirdre; Mariash, Ami et al. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22:1858-67