?s abstract): Theta oscillations (rhythmic, slow-wave activity) have long been studied in rodents and are thought to be important in spatial cognition and memory. Only recently have they been observed in humans. Recording intracranial electroencaphalographic (iEEG) signal from epileptic patients (who were undergoing long-term monitoring for subsequent resection surgery) established that theta was specifically related to a spatial navigation task and to a non-spatial working memory task. Theta was shown to covary with two variables that reflect learning. However, the specific roles of human theta remain unknown. The proposed research will extend the previous findings, analyzing the intracranially recorded neural signal during three tasks to test the effects of cognitively relevant task variables and subject performance on theta activity. Possible roles for theta in spatial cognition, memory and the perceptual characteristics of spatial cognitive tasks will be evaluated. A deeper understanding of human theta oscillations, how they relate to cognition and how they compare with rodent theta will help us to better understand the neurophysiology of cognition and memory, potentially leading to insights on the nature of cognitive disorders, both spatial and memory-related.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH012860-02
Application #
6538366
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Program Officer
Curvey, Mary F
Project Start
2002-04-20
Project End
Budget Start
2002-04-20
Budget End
2003-04-19
Support Year
2
Fiscal Year
2002
Total Cost
$19,090
Indirect Cost
Name
Brandeis University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454