The proposed experiments will use animal models to investigate the physiological origins of sequence memory impairments that have been associated with the dysfunction of the posterior cingulate cortex in humans with Alzheimer's disease. One experiment will measure the behavioral effects of reversible inactivation in the posterior cingulate cortex across early and late stages of sequence learning. This will allow a test of the hypothesis that the posterior cingulate cortex contributes to the learning of new sequences. A second experiment will assess the effects of lesions of cholinergic neurons in the basal forebrain that project to the posterior cingulate cortex, thus testing the role of cholinergic modulation in posterior cingulate function, A third experiment will test the effects of neural inactivation in the dorsal striatum of the basal ganglia, thus testing the hypothesis that the subcortical targets of the cingulate cortex help to encode well-learned visuospatial sequences. Together, the experiments will investigate the basic role of the posterior cingulate cortex in the encoding of sequence memories. They will also allow a better understanding of the structural basis of memory dysfunctions associated with early Alzheimer's disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH070959-02
Application #
6889258
Study Section
Special Emphasis Panel (ZRG1-SCS (20))
Program Officer
Curvey, Mary F
Project Start
2004-03-22
Project End
2005-12-21
Budget Start
2005-03-22
Budget End
2005-12-21
Support Year
2
Fiscal Year
2005
Total Cost
$23,011
Indirect Cost
Name
University of California San Diego
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Cordova, Christopher A; Said, Bishoy O; McCarley, Robert W et al. (2006) Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task. Sleep 29:69-76