The Treatment for Adolescents with Depression Study (TADS) is a randomized controlled trial funded by the National Institute of Mental Health and conducted at 14 sites. A sample of 439 adolescents between 12 and 17 years of age with a diagnosis of major depressive disorder participated in TADS. Participants were randomly assigned to 1 of 4 treatments: cognitive behavior therapy (CBT), fluoxetine (FIX), cognitive behavior therapy in combination with fluoxetine (Combo), or pill placebo (PBO). In addition to primary outcome measures, several additional measures were included in the TADS dataset and will be available for secondary analyses. My research will look at the role of dysfunctional attitudes in the development of adolescent depression. Specifically, I will explore perfectionism as a possible predictor, moderator, and/or mediator of treatment response in terms of depression symptoms and suicidality. Longitudinal data will be available in approximately 1 year and will allow for the testing of models of relations between perfectionism, dysfunctional attitudes, and depression. These findings will contribute to the understanding of cognitive vulnerability for depression and mechanisms of treatment response in depressed adolescents. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH075308-03
Application #
7407566
Study Section
Special Emphasis Panel (ZRG1-F12B-L (20))
Program Officer
Churchill, James D
Project Start
2006-04-01
Project End
2008-06-30
Budget Start
2008-04-01
Budget End
2008-06-30
Support Year
3
Fiscal Year
2008
Total Cost
$9,465
Indirect Cost
Name
Northwestern University at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Jacobs, Rachel H; Becker, Sara J; Curry, John F et al. (2014) Increasing Positive Outlook Partially Mediates the Effect of Empirically Supported Treatments on Depression Symptoms Among Adolescents. J Cogn Psychother 28:3-19
Jacobs, Rachel H; Reinecke, Mark A; Gollan, Jackie K et al. (2010) Extreme thinking in clinically depressed adolescents: Results from the Treatment for Adolescents with Depression Study (TADS). Behav Res Ther 48:1155-9
Jacobs, Rachel H; Becker-Weidman, Emily G; Reinecke, Mark A et al. (2010) Treating depression and oppositional behavior in adolescents. J Clin Child Adolesc Psychol 39:559-67
Ginsburg, Golda S; Silva, Susan G; Jacobs, Rachel H et al. (2009) Cognitive measures of adolescent depression: unique or unitary constructs? J Clin Child Adolesc Psychol 38:790-802
Becker-Weidman, Emily G; Reinecke, Mark A; Jacobs, Rachel H et al. (2009) Predictors of hopelessness among clinically depressed youth. Behav Cogn Psychother 37:267-91
Jacobs, Rachel H; Silva, Susan G; Reinecke, Mark A et al. (2009) Dysfunctional attitudes scale perfectionism: a predictor and partial mediator of acute treatment outcome among clinically depressed adolescents. J Clin Child Adolesc Psychol 38:803-13
Jacobs, Rachel H; Klein, Jesse B; Reinecke, Mark A et al. (2008) Ethnic Differences in Attributions and Treatment Expectancies for Adolescent Depression. Int J Cogn Ther 1:163-178
Jacobs, Rachel H; Reinecke, Mark A; Gollan, Jackie K et al. (2008) Empirical evidence of cognitive vulnerability for depression among children and adolescents: a cognitive science and developmental perspective. Clin Psychol Rev 28:759-82
Klein, Jesse B; Jacobs, Rachel H; Reinecke, Mark A (2007) Cognitive-behavioral therapy for adolescent depression: a meta-analytic investigation of changes in effect-size estimates. J Am Acad Child Adolesc Psychiatry 46:1403-13