Hypertension (HTN) has a complex phenotype with many clinical variations that complicate disease management. African Americans (AA) exhibit the highest rate of HTN and the worst health outcomes, compared to other races. The possible factors that may contribute to race-specific differences in health and disease outcomes have centered around socioeconomic factors as well as differences in pathophysiologic mechanisms, pharmacologic responses, and recently, genetic variability. New findings in gene expression research with animal models have led some to suspect a great possibility for gene expression (measure of mRNA quantity) in the role of HTN. The applicant proposes to examine the roles that race and gene expression of the alpha-1A- and beta-2-adrenergic receptors (ADRs) play in human HTN. The applicant will also examine the relationship between level of alpha-1A- and beta-2-ADR gene expression and vascular tone. This will be a four-arm gene expression study that will primarily compare persons with and without HTN from two race categories -- African Americans and Caucasians. A total of 28 subjects are anticipated with 7 subjects in each arm.
The specific aims of the study will be accomplished by: 1) Collecting left internal mammary artery (LIMA) tissue remnants discarded from coronary artery bypass graft (CABG) patients, and analyzing the tissue for differences in gene expression of the alpha-1A- and beta-2-ADR genes by race and diagnosis; and 2) Comparing post-operative total peripheral resistance (TPR) averages from pre- and post-inotrope administration. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NR009148-01
Application #
6836604
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Huss, Karen
Project Start
2004-09-30
Project End
2006-09-29
Budget Start
2004-09-30
Budget End
2005-09-29
Support Year
1
Fiscal Year
2004
Total Cost
$27,190
Indirect Cost
Name
University of Florida
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Dungan, Jennifer R; Conley, Yvette P; Langaee, Taimour Y et al. (2009) Altered beta-2 adrenergic receptor gene expression in human clinical hypertension. Biol Res Nurs 11:17-26