The applicant is interested in discovering ways to encourage the regeneration of axons in neurons damaged by spinal cord injury. To do this, she plans to focus on both the extrinsic factors (such as extracellular matrix molecules and neurotrophins) and intrinsic characteristics of neurons that support their sprouting and regeneration. Her preliminary work has involved the re-expression of growth-associated proteins in mature neurons after spinal cord lesions followed by fetal spinal cord tissue transplantation and neurotrophin treatment. The research will involve surgery, computer-assisted image analysis to quantify results, and cell and molecular biology techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS010605-04
Application #
6322360
Study Section
Special Emphasis Panel (ZRG2-SSS-F (06))
Program Officer
Heetderks, William J
Project Start
2000-11-01
Project End
Budget Start
2001-03-01
Budget End
2002-05-31
Support Year
4
Fiscal Year
2001
Total Cost
$48,263
Indirect Cost
Name
Georgetown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057