Promoting functional recovery to CNS or PNS injury requires maximizing neuronal survival, facilitating axon growth, remyelination and appropriate synapse formation. This last step is particularly important since formation of new synapses with inappropriate targets could produce maladaptive consequences. Tactile allodynia, characterized by hypersensitivity to innocuous mechanical stimuli, is associated with peripheral neuropathy and has been attributed to the central sprouting of A13 fibers (low threshold mechanoreceptors) into the superficial dorsal horn of the spinal cord, where they form functional synapses with nociceptive neurons that normally relay painful stimuli. We are interested in identifying the molecules and elucidating the mechanisms that enable axon sprouting and aberrant synapse formation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS044718-03
Application #
6789349
Study Section
Special Emphasis Panel (ZRG1-F03A (20))
Program Officer
Kleitman, Naomi
Project Start
2002-08-01
Project End
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
3
Fiscal Year
2004
Total Cost
$28,556
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029