The slow channel syndrome (SCS) is a neuromuscular disorder characterized by fatigability, progressive weakness, and degeneration of the neuromuscular junction. The SCS is caused by missense mutations in the four subunits of the skeletal muscle nAChR. The goal of this proposal is to investigate the mechanisms that lead to the disturbance of the Ca 2+ ionic equilibrium in SCS muscle fibers, and the pathological consequences of this disturbance. To achieve this we will use high-resolution fluorescent imaging in combination with a SCS transgenic murine model. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS047989-01
Application #
6748870
Study Section
Special Emphasis Panel (ZRG1-SCS (29))
Program Officer
Porter, John D
Project Start
2004-05-31
Project End
2006-05-30
Budget Start
2004-05-31
Budget End
2005-05-30
Support Year
1
Fiscal Year
2004
Total Cost
$28,203
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Neurosciences
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455