Recent evidence in vitro has suggested that Bone Morphogenetic Proteins (BMPs) may play a role in regulation of oligodendrogliogenesis, and our recent data suggests that BMP signaling in neural tube may be necessary for oligodendrocyte maturation. However, it is unclear whether BMP signaling to oligodendrocyte lineage cells is necessary for oligodendrogenesis, nor whether this effect persists throughout myelination. This proposal outlines a plan to answer both of these questions using two separate lines of mice in which BMP signaling has been disrupted specifically in the oligodendrocyte lineage.
In Aim 1, I will generate two lines of mice in which BMP signaling is disrupted in oligodendrocyte lineage cells.
In Aim 2, I will determine whether a requirement for BMP signaling to oligodendrocyte lineage cells is required for oligodendrogenesis, whether BMP signaling is necessary for myelination and for myelin maintenance, and whether BMP signaling to oligodendrocyte lineage cells is involved in astrogliogenesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS049848-02
Application #
7215675
Study Section
Special Emphasis Panel (ZRG1-F03A (20))
Program Officer
Mamounas, Laura
Project Start
2005-09-01
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$29,541
Indirect Cost
Name
University of Pennsylvania
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104