The effect of traumatic brain injury on the pharmacological properties of GABAA receptors will be evaluated using whole cell currents in cortical neuronal cultures. Anesthetics will be applied to cultured neurons and patch clamp techniques will be used to evaluate the GABA-mediated currents of cortical neurons. I will determine if stretch-injury alters the functional properties of GABA receptor channels by applying drugs and determining single channel properties. Furthermore, I will determine how stretch-injury effects miniature inhibitory post synaptic currents. This research will help evaluate the cellular and molecular mechanisms that cause TBI, and may aid the development of novel therapies to treat brain injured patients. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS052968-02
Application #
7448533
Study Section
Special Emphasis Panel (ZRG1-BDCN-L (29))
Program Officer
Hicks, Ramona R
Project Start
2006-06-25
Project End
2009-06-24
Budget Start
2007-06-25
Budget End
2008-06-24
Support Year
2
Fiscal Year
2007
Total Cost
$39,688
Indirect Cost
Name
Virginia Commonwealth University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298