The long-term objective of the proposed research is to gain a better understanding of gait abnormalities inParkinson disease (PD). The experiments focus on 1) how decreased arm swing may be related tobradykinesia and/or rigidity, 2) exploring the mechanisms underlying turning difficulties and freezing and 3)adaptive capacity in the control of locomotor trajectory after stepping on a rotating treadmill in subjects withPD.
Specific Aim 1 explores the relationships among arm swing, bradykinesia and rigidity.
Specific Aim 2 examines the kinematic and electromyographic characteristics of turning and freezing.
Specific Aim 3 looksat the effect of podokinetic stimulation (i.e.stepping on a rotating treadmill) and the applicability of using therotating treadmill as a rehabilitative tool. Previous studies have noted that healthy individuals, following anadaptation phase of stepping on a rotating treadmill, inadvertently turn when asked to walk in place. Wewant to determine whether PD subjects demonstrate this adaptive response and furthermore whethertreadmill training can enhance turning.The proposed research is very relevant to public health. PD is a neurodegenerative disease that affectsmore than 1 million people in America. As the US population ages the prevalence of PD will progressivelyincrease and involve more of the general population. Addressing problems with walking in this patientpopulation is crucial because these problems can pose a threat to functional independence. Moreover,turning difficulties may increase risks for falls, potentially leading to more complications.
| Hong, Minna; Earhart, Gammon M (2010) Effects of medication on turning deficits in individuals with Parkinson's disease. J Neurol Phys Ther 34:11-6 |
| Hong, Minna; Perlmutter, Joel S; Earhart, Gammon M (2009) A kinematic and electromyographic analysis of turning in people with Parkinson disease. Neurorehabil Neural Repair 23:166-76 |
| Hong, Minna; Earhart, Gammon M (2008) Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations. Parkinsonism Relat Disord 14:359-63 |
