The long term objectives of this research proposal are to achieve an understanding of the neurobiology of the novel neuropeptide, cortistatin. Neuropeptides are biological signaling molecules that modulate a wide range of physiological functions such as synaptic transmission, and are involved in many health related conditions including Alzheimer's disease, cognitive deficiencies and sleep disorders. The neuropeptide cortistatin was recently cloned and the aims of this proposal are to confirm that this neuropeptide is expressed in the brain, released as a neurotransmitter, binds to specific sites in the brain and through these receptors causes physiological responses. The proposed characterization of cortistatin will facilitate the isolation or identification of cortistatin specific receptors; a vital element in understanding the signaling mechanisms of this novel neuropeptide and in providing a target for medically relevant compounds to treat disease states and disorders of the nervous systems.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AG005882-01
Application #
6134813
Study Section
Special Emphasis Panel (ZRG1-MDCN-5 (01))
Program Officer
Wise, Bradley C
Project Start
2000-03-01
Project End
Budget Start
2000-03-01
Budget End
2003-02-28
Support Year
1
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037