The long-term goal of the proposed research is to develop mechanistically well-characterized inhibitors of Beta-amyloid aggregation and Alzheimer?s disease. The specific goal of this project is to apply the concept of divalent mistemplation to the design and synthesis of a library of molecules made up of peptides attached to spatially diverse scaffolds. These molecules will be screened to determine key elements needed for various anti-amyloid activities. Conclusions will then be established about structure-activity relationships for the inhibitors and that information will be applied to the next generation of compounds.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AG019550-02
Application #
6657963
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Buckholtz, Neil
Project Start
2002-10-01
Project End
Budget Start
2002-09-30
Budget End
2003-09-29
Support Year
2
Fiscal Year
2002
Total Cost
$38,320
Indirect Cost
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Derda, Ratmir; Musah, Samira; Orner, Brendan P et al. (2010) High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells. J Am Chem Soc 132:1289-95
Derda, Ratmir; Li, Lingyin; Orner, Brendan P et al. (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol 2:347-55
Orner, Brendan P; Liu, Lin; Murphy, Regina M et al. (2006) Phage display affords peptides that modulate beta-amyloid aggregation. J Am Chem Soc 128:11882-9
Orner, Brendan P; Derda, Ratmir; Lewis, Rachel L et al. (2004) Arrays for the combinatorial exploration of cell adhesion. J Am Chem Soc 126:10808-9