Factors that affect measurement of Quality of Life (QOL) in Mild Cognitive Impairment (MCI) and Alzheimer?s disease (AD) are critical to identify. The proposed study will examine associations between insight and QOL in three groups of elderly individuals known to differ in degree of cognitive impairment and insight. QOL in MCI, AD, and controls will be measured by self- and caregiver-report. Insight will be measured by clinician ratings and by discrepancies between ratings of patients? abilities by selves and caregivers on memory and functional inventories. Caregiver-reported QOL is expected to be greatest in controls, lower in MCI, and lowest in AD. Self-reported QOL is expected to be lower in MCI as compared to controls but reports are not expected to differ between MCI and AD. Thus, differences between self- and caregiver reports are predicted. Greater lack of insight in patients is expected to be associated with increased discrepancy between self- and caregiver-reports of patient QOL. Findings will facilitate the development of future research on QOL in cognitively impaired elderly directed at identification of means to enhance QOL in this population.
| Ready, Rebecca E; Ott, Brian R (2007) Integrating patient and informant reports on the Cornell-Brown Quality-of-Life Scale. Am J Alzheimers Dis Other Demen 22:528-34 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet (2007) Factor structure of patient and caregiver ratings on the dementia quality of life instrument. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:144-54 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet (2006) Insight and cognitive impairment: effects on quality-of-life reports from mild cognitive impairment and Alzheimer's disease patients. Am J Alzheimers Dis Other Demen 21:242-8 |
| Ready, Rebecca E; Clark, Lee Anna (2005) Psychiatric patient and informant reports of patient behavior. J Pers 73:1-22 |
| Ready, R E; Friedman, J; Grace, J et al. (2004) Testosterone deficiency and apathy in Parkinson's disease: a pilot study. J Neurol Neurosurg Psychiatry 75:1323-6 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet (2004) Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease. Int J Geriatr Psychiatry 19:256-65 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet (2004) Validity of informant reports about AD and MCI patients' memory. Alzheimer Dis Assoc Disord 18:11-6 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet (2003) Amnestic behavior in dementia: symptoms to assist in early detection and diagnosis. J Am Geriatr Soc 51:32-7 |
| Ready, Rebecca E; Ott, Brian R; Grace, Janet et al. (2003) Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry 11:222-8 |
| Ready, Rebecca E; Ott, Brian R (2003) Quality of Life measures for dementia. Health Qual Life Outcomes 1:11 |
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