Dr. LaFerla's laboratory has generated a novel triple transgenic animal model of Alzheimer's Disease (AD). This model harbors three transgenes relevant to the genetic forms of AD and develops all of the neuropathological hallmarks of the disease, including Abeta plaques, neurofibrillary tangles and synaptic deficits including deficits in LTP. In addition, these neuropathological changes in the triple trangenic mice (3xTg-AD) mimic the time course of the progression of the disease in humans. Therefore, the 3xTg-AD mice represent the best animal model of AD to date. The research proposed in this application is concerned with identifying the cognitive phenotype of the 3xTg-AD mice to determine (1) the time course of the development of any behavioral impairments on a variety of memory-related tasks and (2) whether any changes in performance on memory-related tasks correlate with the deposition of Abeta and tau.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AG024035-01
Application #
6790442
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Snyder, Stephen D
Project Start
2004-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$42,976
Indirect Cost
Name
University of California Irvine
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Clinton, Lani K; Billings, Lauren M; Green, Kim N et al. (2007) Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis 28:76-82
Billings, Lauren M; Oddo, Salvatore; Green, Kim N et al. (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45:675-88