The overall objective of this proposal is to understand of the role of integrin cell adhesion receptors in the regulation of immune responses. By understanding the ways in which integrins, their ligands and downstream effectors can regulate immune cells it may be possible to selectively regulate the immune system to prevent inappropriate immune responses and induce beneficial ones. This proposal addresses a mechanism of T cell regulation called transdominant suppression in which ligation of one integrin can selectively inhibit the ability of other integrins to activate.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI010601-02
Application #
6510069
Study Section
Special Emphasis Panel (ZRG1-IMB (20))
Program Officer
Prograis, Lawrence J
Project Start
2002-03-01
Project End
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
2
Fiscal Year
2002
Total Cost
$48,148
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Microbiology/Immun/Virology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030