The conservation of the innate immune response signaling pathway in Drosophila, mice and humans has been well documented, and involves the recognition of pathogen-associated molecular patterns (PAMPs) by Toll-like receptors. A substantial body of both published work and preliminary results concerning signaling pathways that respond to the bacterial flagellar peptide, Flg22, or to oligogalacturonides (OGs) often released from plant cell walls upon pathogen infection has shown that both OGs and Flg22 behave as PAMPs and that their signaling pathways confer basal resistance to a wide spectrum of pathogens. Two general hypotheses that we propose to test are (1) that among the characterized plant immune response pathways, the OG and Flg22 pathways are among the most ancient and most similar to the so-called """"""""Toll-like"""""""" innate immune signaling pathways characterized in Drosophila and mammals, and (2) that disease-causing pathogens have evolved virulence factors to target and block PAMP-elicited resistance. My goals are to identify Pseudomonas syringae type III effectors that disrupt or modify the OG signaling pathway to enhance pathogen virulence, and then to identify the OG signaling targets of these virulence effectors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AI066817-01
Application #
6999976
Study Section
Special Emphasis Panel (ZRG1-F13 (20))
Program Officer
Taylor, Christopher E,
Project Start
2005-06-06
Project End
2008-06-05
Budget Start
2005-06-06
Budget End
2006-06-05
Support Year
1
Fiscal Year
2005
Total Cost
$42,068
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Clay, Nicole K; Adio, Adewale M; Denoux, Carine et al. (2009) Glucosinolate metabolites required for an Arabidopsis innate immune response. Science 323:95-101