Normal development of hair follicles of the skin results from the carefully regulated balance of differentiation and proliferation through which hair follicles are continually grow and shed. A tight equilibrium between divisions and differentiation fuels the production of the new hair growth. Almost nothing is known about how this happens, and yet the step is a critical one. If there are too few rounds of division, hair growth stops prematurely; if there are too many rounds, tumors can arise. The hair follicle is thought to be the origin of basal cell carcinomas, trichofolliculumas and pilomatricomas. Recent evidence suggests that growth factor signaling pathways through PI3K play a key role in hair follicle proliferation and malignancy. Although canonical signaling through AKT has significant importance in mediating PI3K pathway in many cancers, there a paucity of evidence that disruption of AKT isoforms effects growth and differentiation in the context of hair follicles. Recent reports indicate a more prominent and novel role for the serum- and glucocorticoid-regulated kinases (SGK) in modulating growth factor-stimulated proliferation in hair follicles of the skin. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AR053419-03
Application #
7469562
Study Section
Special Emphasis Panel (ZRG1-F10 (20))
Program Officer
Baker, Carl
Project Start
2006-08-01
Project End
2009-01-31
Budget Start
2008-08-01
Budget End
2009-01-31
Support Year
3
Fiscal Year
2008
Total Cost
$29,564
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195