Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA067493-02
Application #
2111206
Study Section
Pathology A Study Section (PTHA)
Project Start
1997-07-01
Project End
Budget Start
1996-03-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hippen, K L; O'Connor, R S; Lemire, A M et al. (2017) In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines. Am J Transplant 17:3098-3113
Lu, Yunjie; Hippen, Keli L; Lemire, Amanda L et al. (2016) miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency. Blood 128:1424-35
Singh, K; Stempora, L; Harvey, R D et al. (2014) Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. Am J Transplant 14:2691-703
Sawitzki, Birgit; Brunstein, Claudio; Meisel, Christian et al. (2014) Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression. Biol Blood Marrow Transplant 20:173-82
Hawasli, Ammar H; Rubin, Joshua B; Tran, David D et al. (2013) Antiangiogenic agents for nonmalignant brain tumors. J Neurol Surg B Skull Base 74:136-41
Singh, K; Kozyr, N; Stempora, L et al. (2012) Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus. Am J Transplant 12:1441-57
Zanin-Zhorov, Alexandra; Lin, Jiqiang; Scher, Jose et al. (2012) Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci U S A 109:1625-30
Hippen, Keli L; Bucher, Christoph; Schirm, Dawn K et al. (2012) Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood 119:619-28
Plesa, Gabriela; Zheng, Lingjie; Medvec, Andrew et al. (2012) TCR affinity and specificity requirements for human regulatory T-cell function. Blood 119:3420-30
Hippen, K L; Merkel, S C; Schirm, D K et al. (2011) Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant 11:1148-57

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