Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA080396-02
Application #
6174239
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Lohrey, Nancy
Project Start
2000-04-01
Project End
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$37,516
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Jez, Joseph M; Bowman, Marianne E; Noel, Joseph P (2002) Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry 41:5168-76
Jez, Joseph M; Bowman, Marianne E; Noel, Joseph P (2002) Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc Natl Acad Sci U S A 99:5319-24
Jez, J M; Bowman, M E; Noel, J P (2001) Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry 40:14829-38
Penning, T M; Jez, J M (2001) Enzyme redesign. Chem Rev 101:3027-46
Jez, J M; Ferrer, J L; Bowman, M E et al. (2000) Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39:890-902
Jez, J M; Austin, M B; Ferrer, J et al. (2000) Structural control of polyketide formation in plant-specific polyketide synthases. Chem Biol 7:919-30
Jez, J M; Noel, J P (2000) Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. J Biol Chem 275:39640-6