This project consists of a systematic approach to investigate the structural information of the Tar chemoreceptor. The primary goal is elucidation of the fundamental mechanism of transmembrane signal transduction. The aspartate receptor is unique in that it has been well characterized which will allow our question to be approached. X-ray crystallography as well as electron microscopy will be used to resolve the structures of this receptor, with and without bound aspartate, at atomic resolution. Information from this study can be applied to other transduction receptors. Signal transduction is a phenomenon that occurs in all cell types. Bacterial chemotaxis and mammalian signal transduction both involve transmembrane signal transduction. Mutated forms of mammalian signal transduction proteins are often oncogenic. Therefore, a deeper understanding of the mechanisms of transmembrane signaling will lead to a better understanding of the events that cause cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32CA081718-01
Application #
2862733
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Lohrey, Nancy
Project Start
1999-10-05
Project End
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704