The long term goal of this proposal is to study signaling in the context of transformed cells and how transformed cells switch to a more aggressive phenotype. The study will focus on the pleiotrophin (PTN) signaling pathway which has been shown to transform cells and initiate angiogenesis. Much of the initial work will be to find interactive proteins with the cytoplasmic domain of the transmembrane tyrosine phosphatase, receptor protein tyrosine phosphatase (RPTP) beta/zeta. Following the identification of these proteins, their roles as downstream elements of this pathway will be characterized. The major aim of this proposal is to identify characterize the role of proteins interactive with the cytoplasmic domain of RPTP beta/zeta in promoting the PTN signal. If time and effort permit, I plan to seek the specific sites in beta-catenin that have increased tyrosine phosphorylation in PTN-stimulated cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA091768-03
Application #
6619611
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Lohrey, Nancy
Project Start
2003-01-29
Project End
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2003
Total Cost
$48,148
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
International Glossina Genome Initiative (2014) Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science 344:380-6