Anal carcinoma is a common malignancy in HIV positive men with an incidence 80 times higher than the general population. It is preceded by Anal Squamous Intraepithelial Lesions (ASIL) and has anal human papillomavirus (HPV) as a major risk factor. An effective screening program for these conditions would allow treatment before invasive disease is established and may reduce the incidence of anal carcinoma in these men. Previous studies have shown the viability and cost- effectiveness of screening certain groups of HIV positive men. The populations examined in these studies have been mainly white men who have sex with men. At Columbia-Presbyterian Medical Center (CPMC), our HIV clinic is comprised of a diverse population including 50% Hispanics, 40% African-Americans and half who do not report having sex with men as a risk factor for HIV. The prevalence of ASIL and anal HPV infection in these groups of men is unknown. The study proposed here will help determine this information and suggest which of these men may benefit from screening for anal carcinoma. 200 HIV positive men from the Infectious Diseases clinic at CPMC will be enrolled. They will be examined with anal cytology, anal cytobrush in a liquid medium, HPV DNA PCR, and high resolution anoscopy with biopsy. A detailed sexual and behavioral questionnaire will be administered and immunologic parameters obtained from the clinic chart. This information will then be correlated to the presence of ASIL and HPV infection to elucidate the risk factors for these premalignant conditions. This pilot study will form the basis for subsequent multi-center trials to determine the sensitivity, specificity, positive and negative predictive values of these tests in an effort to bring this screening into the standard clinical care of HIV positive men.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA093140-02
Application #
6515255
Study Section
AIDS and Related Research 8 (AARR)
Program Officer
Lohrey, Nancy
Project Start
2002-07-01
Project End
Budget Start
2002-07-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$10,514
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Weber, Kari A; Heaphy, Christopher M; Joshu, Corinne E et al. (2018) Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations. Cancer Causes Control 29:759-767
Weber, Kari A; Heaphy, Christopher M; Rohrmann, Sabine et al. (2016) Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer? Prostate Cancer 2016:3691650