Human papillomaviruses (HPV) are important communicable pathogens and are the causative agent of many anogenital cancers, in particular cervical cancer. Approximately 95 percent of cervical cancers have been linked to high-risk variants of HPV and cause approximately 200,000 deaths per year worldwide. Papillomaviruses are small non-enveloped DNA tumor viruses with a genome of approximately 8 Kb in length that encodes 8-10 gene products. I am interested in the entry mechanism HPV uses to enter the host cell. To study this question I plan to use pseudovirions to investigate interactions between HPV and proteins on the surface of the host cell and the early entry events that lead to infection of the host cell. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA097798-03
Application #
6898906
Study Section
Special Emphasis Panel (ZRG1-F08 (20))
Program Officer
Lohrey, Nancy
Project Start
2003-07-01
Project End
2005-08-31
Budget Start
2005-07-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2005
Total Cost
$8,592
Indirect Cost
Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611