Nearly two decades of research with primarily healthy samples have documented that writing about one's emotions associated with negative events over several brief sessions can enhance physical and psychological well-being. Promising studies with predominantly early-stage cancer patients suggest that expressive writing produces health benefits such as reduced pain and medical visits for cancer-related morbidities. Research to date has not examined the potential benefits of expressive writing for women with metastatic breast cancer who confront a growing dependence on others, cognitive and physical decline, and the ultimate prospect of death. Data suggest that most advanced cancer patients desire to share their cancer-related thoughts and feelings with others and view emotional and existential concerns as very important. Yet, some patients feel constrained in discussing their cancer-related experiences, and very few formal interventions have been developed to help cancer patients cope with end-of-life concerns. In this study, 74 women with Stage IV breast cancer will be randomly assigned to one of two conditions: 1) emotional disclosure writing intervention, or 2) control writing. Women in the emotional disclosure writing condition will write about their deepest thoughts and feelings regarding their breast cancer experience, whereas women in the control writing condition will write about their daily activities in a detailed manner. Women in both conditions will be asked to complete four, 20-minute writing sessions that are administered via telephone. Assessments will be conducted before the intervention and at 8 weeks post- intervention. Primary outcomes include indices of distress (i.e., depressive symptoms and demoralization), and secondary outcomes include a sense of meaning in life and peace, pain severity, sleep disturbance, fatigue, and functional impairment. We hypothesize that women assigned to the emotional disclosure writing condition will experience better psychological and physical health at follow-up relative to controls. We also hypothesize that the writing intervention will be most beneficial for women who feel constrained in discussing their cancer experience with others. This study will provide new information regarding the feasibility and utility of a telephone- administered expressive writing intervention for advanced cancer patients. Consistent with the mission of the National Cancer Institute, this research aims to promote public health by reducing adverse outcomes of cancer and its treatment and enhancing patients' well-being. Results of this project have the potential to inform future studies of emotional disclosure interventions for cancer patients and clinical practice. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA130600-02
Application #
7616188
Study Section
Special Emphasis Panel (ZRG1-F11-K (20))
Program Officer
Myrick, Dorkina C
Project Start
2007-09-21
Project End
2010-09-20
Budget Start
2008-09-21
Budget End
2009-09-20
Support Year
2
Fiscal Year
2008
Total Cost
$46,826
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Mosher, C E; Given, B A; Ostroff, J S (2015) Barriers to mental health service use among distressed family caregivers of lung cancer patients. Eur J Cancer Care (Engl) 24:50-9
Mosher, Catherine E; Johnson, Courtney; Dickler, Maura et al. (2013) Living with metastatic breast cancer: a qualitative analysis of physical, psychological, and social sequelae. Breast J 19:285-92
Mosher, Catherine E; Jaynes, Heather A; Hanna, Nasser et al. (2013) Distressed family caregivers of lung cancer patients: an examination of psychosocial and practical challenges. Support Care Cancer 21:431-7
Mosher, Catherine E; Champion, Victoria L; Azzoli, Christopher G et al. (2013) Economic and social changes among distressed family caregivers of lung cancer patients. Support Care Cancer 21:819-26
Mosher, Catherine E; Champion, Victoria L; Hanna, Nasser et al. (2013) Support service use and interest in support services among distressed family caregivers of lung cancer patients. Psychooncology 22:1549-56
Mosher, Catherine E; Duhamel, Katherine N; Lam, Joanne et al. (2012) Randomised trial of expressive writing for distressed metastatic breast cancer patients. Psychol Health 27:88-100
Mosher, Catherine E; Duhamel, Katherine N (2012) An examination of distress, sleep, and fatigue in metastatic breast cancer patients. Psychooncology 21:100-7
Mosher, Catherine E; DuHamel, Katherine N; Rini, Christine et al. (2011) Quality of life concerns and depression among hematopoietic stem cell transplant survivors. Support Care Cancer 19:1357-65
Mosher, Catherine E; Danoff-Burg, Sharon (2010) Addiction to indoor tanning: relation to anxiety, depression, and substance use. Arch Dermatol 146:412-7
DuHamel, Katherine N; Mosher, Catherine E; Winkel, Gary et al. (2010) Randomized clinical trial of telephone-administered cognitive-behavioral therapy to reduce post-traumatic stress disorder and distress symptoms after hematopoietic stem-cell transplantation. J Clin Oncol 28:3754-61

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